Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature
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چکیده
منابع مشابه
Growth Hormone Responses to Provocative Tests in Children with Short Stature
Growth hormone deficiency (GHD) is defined as a serum peak GH concentration <10 ng/mL with provocation as tested by a combination of at least two separate tests. The aim of this study was to compare two standard tests, insulin and levodopa (L-dopa), with a primary focus on specificity and accuracy. Clinical data were collected retrospectively from a review of 120 children who visited the pediat...
متن کاملGrowth Hormone in the Treatment of Children with Short Stature
Therapeutic use of growth hormone (GH) in the United States generally has been restricted to GHdeficient children who, with their families, agree to participate in research. The limited supply and the considerable expense of commercially prepared GH have restricted the number of children who have received such therapy. As the medical community and public become more aware of the therapeutic pot...
متن کاملGrowth hormone receptor mutations in children with idiopathic short stature.
Homozygous or compound heterozygous mutations in the GH receptor (GHR) gene result in GH insensitivity syndrome. Previous reports have shown that some heterozygous mutations may induce a partial insensitivity to GH, but others appear to have limited effect on growth. To investigate further these observations, we analyzed the GHR gene in 17 subjects with idiopathic short stature (ISS). All subje...
متن کاملGrowth Hormone in the Treatment of Children with Short Stature
Therapeutic use of growth hormone (GH) in the United States generally has been restricted to GHdeficient children who, with their families, agree to participate in research. The limited supply and the considerable expense of commercially prepared GH have restricted the number of children who have received such therapy. As the medical community and public become more aware of the therapeutic pot...
متن کاملGrowth Hormone in the Treatment of Children with Short Stature
Therapeutic use of growth hormone (GH) in the United States generally has been restricted to GHdeficient children who, with their families, agree to participate in research. The limited supply and the considerable expense of commercially prepared GH have restricted the number of children who have received such therapy. As the medical community and public become more aware of the therapeutic pot...
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ژورنال
عنوان ژورنال: Reviews in Endocrine and Metabolic Disorders
سال: 2021
ISSN: 1389-9155,1573-2606
DOI: 10.1007/s11154-021-09637-1